Accidental Administration of Ionic Contrast Medium through Intrathecal Route

Accidental intrathecal administration of high dose diamorphine.

A case of accidental administration of high dose intrathecal diamorphine is reported in a patient who underwent total knee replacement. Initially a regional technique was planned for this patient, but due to inadvertent administration of three milligrams of diamorphine intrathecally, it was decided to convert the patient to have a general anaesthetic. Postoperatively, she was monitored in high ...

Neural toxicity induced by accidental intrathecal vincristine administration.

Described here is a case of accidental intrathecal administration of vincristine with pathologic findings in the central nervous system. A 3-year-old boy with acute lymphoblastic leukemia, was given his ninth course chemotherapy. Vincristine was accidentally injected intrathecally. The clinical course was rapidly progressive (6-day course) and resulted in death. An autopsy was done. The brain a...

Inadvertent intrathecal use of ionic contrast media for myelography.

PURPOSE To describe instances of inadvertent intrathecal injection of ionic contrast media and to consider treatment approaches, and diagnostic and medicolegal issues. METHODS Ten cases of inadvertent injection, of which nine were reported to the manufacturers/authors and one appeared in the literature, are related with emphasis on similarity of reactions. RESULTS Six criteria are enumerate...

Accidental intrathecal methotrexate overdose.

Brain parenchyma penetration by intrathecal ionic and nonionic contrast media.

Metrizamide, a nonionic water-soluble contrast medium, has been shown to penetrate normal brain when injected intrathecally. Recently it was suggested that the complications following intrathecal metrizamide are directly related to the cerebral concentration reached. Metrizamide, both in experimental animals and clinically, is regarded as less neurotoxic than equivalent iodine concentrations of...